Transport of folate compounds by leukemic cells. Evidence for a single influx carrier for methotrexate, 5-methyltetrahydrofolate, and folate in CCRF-CEM human lymphoblasts.

@article{Henderson1987TransportOF,
  title={Transport of folate compounds by leukemic cells. Evidence for a single influx carrier for methotrexate, 5-methyltetrahydrofolate, and folate in CCRF-CEM human lymphoblasts.},
  author={G. Henderson and J. Tsuji and H. P. Kumar},
  journal={Biochemical pharmacology},
  year={1987},
  volume={36 18},
  pages={
          3007-14
        }
}
  • G. Henderson, J. Tsuji, H. P. Kumar
  • Published 1987
  • Chemistry, Medicine
  • Biochemical pharmacology
  • Influx kinetics and inhibitor specificity have been compared for the transport of methotrexate, 5-methyltetrahydrofolate, and folate in CCRF-CEM human lymphoblastoid cells. Influx of each folate compound proceeded with approximately the same Vmax, fluctuated in the same fashion with the ionic composition of the medium, and was blocked by low concentrations of an N-hydroxysuccinimide ester of methotrexate in both an anion-deficient buffer and in a buffered saline medium containing physiological… CONTINUE READING
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    The biological chemistry of folate receptors.
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