Transport of folate compounds by leukemic cells. Evidence for a single influx carrier for methotrexate, 5-methyltetrahydrofolate, and folate in CCRF-CEM human lymphoblasts.

@article{Henderson1987TransportOF,
  title={Transport of folate compounds by leukemic cells. Evidence for a single influx carrier for methotrexate, 5-methyltetrahydrofolate, and folate in CCRF-CEM human lymphoblasts.},
  author={G. Henderson and J. Tsuji and H. P. Kumar},
  journal={Biochemical pharmacology},
  year={1987},
  volume={36 18},
  pages={
          3007-14
        }
}
  • G. Henderson, J. Tsuji, H. P. Kumar
  • Published 1987
  • Chemistry, Medicine
  • Biochemical pharmacology
    • Influx kinetics and inhibitor specificity have been compared for the transport of methotrexate, 5-methyltetrahydrofolate, and folate in CCRF-CEM human lymphoblastoid cells. Influx of each folate compound proceeded with approximately the same Vmax, fluctuated in the same fashion with the ionic composition of the medium, and was blocked by low concentrations of an N-hydroxysuccinimide ester of methotrexate in both an anion-deficient buffer and in a buffered saline medium containing physiological… CONTINUE READING
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    29 Citations
    Background Citations
    7
    Methods Citations
    1
    29 Citations
    Citation Type

    Citation Type

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    Molecular events in the membrane transport of methotrexate in human CCRF-CEM leukemia cell lines.
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    Simultaneous changes in various mechanisms that mediate the cell incorporation of folate compounds account for low levels of resistance to methotrexate
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    Impact of Overexpression of the Reduced Folate Carrier (RFC1), an Anion Exchanger, on Concentrative Transport in Murine L1210 Leukemia Cells*
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    Interaction of methotrexate polyglutamates and dihydrofolate during leucovorin rescue in a human breast cancer cell line (MCF-7).
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    ( MCF-7 ) during Leucovorin Rescue in a Human Breast Cancer Cell Line Interaction of Methotrexate Polyglutamates and Dihydrofolate Updated
    The role of folates in the development of methotrexate resistance in human leukemia cell line K562
    • 2
    The biological chemistry of folate receptors.
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    • PDF
    Mechanism of leucovorin reversal of methotrexate cytotoxicity in human MCF-7 breast cancer cells.
    • 15

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