Transport of fluorescein in MDCKII-MRP1 transfected cells and mrp1-knockout mice.

  title={Transport of fluorescein in MDCKII-MRP1 transfected cells and mrp1-knockout mice.},
  author={H. Sun and D. R. Johnson and R. A. Finch and A. Sartorelli and D. Miller and W. Elmquist},
  journal={Biochemical and biophysical research communications},
  volume={284 4},
  • H. Sun, D. R. Johnson, +3 authors W. Elmquist
  • Published 2001
  • Biology, Medicine
  • Biochemical and biophysical research communications
  • The multidrug resistant-associated protein 1 (MRP1) is a membrane-bound transport protein that is involved in the efflux of organic anions and has been implicated in multidrug resistance in cancer. MRP1 has also been reported to be ubiquitously expressed in normal tissues, including the brain. The presence of functional organic anion transporters in the blood-brain and blood-CSF barriers that influence the distribution of various compounds to the brain has long been known. The purpose of this… CONTINUE READING
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