Transport of estradiol-17β-glucuronide, estrone-3-sulfate and taurocholate across the endoplasmic reticulum membrane: evidence for different transport systems☆

@inproceedings{Wlcek2014TransportOE,
  title={Transport of estradiol-17β-glucuronide, estrone-3-sulfate and taurocholate across the endoplasmic reticulum membrane: evidence for different transport systems☆},
  author={Katrin Wlcek and Lia Hofstetter and Bruno Stieger},
  booktitle={Biochemical pharmacology},
  year={2014}
}
Important reactions of drug metabolism, including UGT mediated glucuronidation and steroidsulfatase mediated hydrolysis of sulfates, take place in the endoplasmic reticulum (ER) of hepatocytes. Consequently, UGT generated glucuronides, like estradiol-17β-glucuronide, have to be translocated back into the cytoplasm to reach their site of excretion. Also steroidsulfatase substrates, including estrone-3-sulfate, have to cross the ER membrane to reach their site of hydrolysis. Based on their… CONTINUE READING

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Transport of estradiol-17β-glucuronide , estrone-3-sulfate and taurocholate across the endoplasmic reticulum membrane : evidence for different transport systems☆. Important reactions of drug metabolism , including UGT mediated glucuronidation and steroidsulfatase mediated hydrolysis of sulfates , take place in the endoplasmic reticulum ( ER ) of hepatocytes .
Transport of estradiol-17β-glucuronide , estrone-3-sulfate and taurocholate across the endoplasmic reticulum membrane : evidence for different transport systems☆. Important reactions of drug metabolism , including UGT mediated glucuronidation and steroidsulfatase mediated hydrolysis of sulfates , take place in the endoplasmic reticulum ( ER ) of hepatocytes .
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