Transport of drugs by proton-coupled peptide transporters: pearls and pitfalls.

@article{Brandsch2009TransportOD,
  title={Transport of drugs by proton-coupled peptide transporters: pearls and pitfalls.},
  author={Matthias Brandsch},
  journal={Expert opinion on drug metabolism & toxicology},
  year={2009},
  volume={5 8},
  pages={887-905}
}
The pharmaceutical relevance of proton-coupled peptide transporters is currently under intense investigation in many laboratories. Studies have shown that these membrane proteins, expressed in intestine, kidney, choroid plexus and other tissues, accept many peptidomimetic drugs and prodrugs as substrates. The focus of this review is on the interaction of beta-lactam antibiotics, angiotensin-converting enzyme inhibitors, sartans and other drugs with PEPT1 and PEPT2. The article highlights… CONTINUE READING
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