Corpus ID: 44656968

Transport of digoxin by human P-glycoprotein expressed in a porcine kidney epithelial cell line (LLC-PK1).

@article{Tanigawara1992TransportOD,
  title={Transport of digoxin by human P-glycoprotein expressed in a porcine kidney epithelial cell line (LLC-PK1).},
  author={Yusuke Tanigawara and N. Okamura and Midori Hirai and Mikiko Yasuhara and Kazumitsu Ueda and Noriyuki Kioka and Tohru Komano and Ryohei Hori},
  journal={The Journal of pharmacology and experimental therapeutics},
  year={1992},
  volume={263 2},
  pages={
          840-5
        }
}
This article represents the first evidence that the renal secretion of the commonly used drug, digoxin, is mediated by P-glycoprotein. In this study, it was demonstrated that digoxin is a substrate of P-glycoprotein, and the mechanism of a clinically important drug interaction, such as digoxin-quinidine, was elucidated. Human P-glycoprotein was expressed on the apical membrane of the porcine kidney epithelial cell line, LLC-PK1 by transfecting with human MDR1 cDNA. The expression and function… Expand
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