Transport of dicationic drugs pentamidine and furamidine by human organic cation transporters.

@article{Ming2009TransportOD,
  title={Transport of dicationic drugs pentamidine and furamidine by human organic cation transporters.},
  author={Xin Ming and Wujian Ju and Huali Wu and Richard R. Tidwell and James Edwin Hall and Dhiren R. Thakker},
  journal={Drug metabolism and disposition: the biological fate of chemicals},
  year={2009},
  volume={37 2},
  pages={424-30}
}
The antiparasitic activity of aromatic diamidine drugs, pentamidine and furamidine, depends on their entry into the pathogenic protozoa via membrane transporters. However, no such diamidine transporter has been identified in mammalian cells. The goal of this study is to investigate whether these dicationic drugs are substrates for human organic cation transporters (hOCTs, solute carrier family 22A1-3) and whether hOCTs play a role in their tissue distribution, elimination, and toxicity… CONTINUE READING

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