Transport of choline out of the cranial cerebrospinal fluid spaces of the rabbit.

@article{Lanman1980TransportOC,
  title={Transport of choline out of the cranial cerebrospinal fluid spaces of the rabbit.},
  author={Robert C. Lanman and L. S. Schanker},
  journal={The Journal of pharmacology and experimental therapeutics},
  year={1980},
  volume={215 3},
  pages={563-8}
}
The role which carrier-mediated transport and passive diffusion play in the clearance of quaternary ammonium compounds from cerebrospinal fluid was evaluated by ventriculocisternal perfusion in rabbits by using [14C]choline as the primary test compound. Choline was transported out of cerebrospinal fluid by two processes: a saturable, carrier-mediated process with a Tmax of 70.5 ng/min and Kt of 2.2 microgram/min; and, a passive nonsaturable process with a cerebrospinal fluid perfusate clearance… CONTINUE READING

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