Transport of butyryl-L-carnitine, a potential prodrug, via the carnitine transporter OCTN2 and the amino acid transporter ATB(0,+).

@article{Srinivas2007TransportOB,
  title={Transport of butyryl-L-carnitine, a potential prodrug, via the carnitine transporter OCTN2 and the amino acid transporter ATB(0,+).},
  author={Sonne R Srinivas and Puttur D Prasad and Nagavedi Siddaramappa Umapathy and Vadivel Ganapathy and Prem S Shekhawat},
  journal={American journal of physiology. Gastrointestinal and liver physiology},
  year={2007},
  volume={293 5},
  pages={G1046-53}
}
L-carnitine is absorbed in the intestinal tract via the carnitine transporter OCTN2 and the amino acid transporter ATB(0,+). Loss-of-function mutations in OCTN2 may be associated with inflammatory bowel disease (IBD), suggesting a role for carnitine in intestinal/colonic health. In contrast, ATB(0,+) is upregulated in bowel inflammation. Butyrate, a bacterial fermentation product, is beneficial for prevention/treatment of ulcerative colitis. Butyryl-L-carnitine (BC), a butyrate ester of… CONTINUE READING