Transport of anthelmintic benzimidazole drugs by breast cancer resistance protein (BCRP/ABCG2).

@article{Merino2005TransportOA,
  title={Transport of anthelmintic benzimidazole drugs by breast cancer resistance protein (BCRP/ABCG2).},
  author={Gracia Merino and Johan W. Jonker and E. B. Wagenaar and Mivis M Pulido and Antonio Jos{\'e} Molina and Ana Isabel {\'A}lvarez and Alfred H Schinkel},
  journal={Drug metabolism and disposition: the biological fate of chemicals},
  year={2005},
  volume={33 5},
  pages={614-8}
}
Methylcarbamate benzimidazoles [albendazole (ABZ), fenbendazole (FBZ), and their respective sulfoxide derivatives, albendazole sulfoxide (ABZSO) and oxfendazole (OXF)] are therapeutically important anthelmintic agents with low bioavailability. We studied their in vitro interaction with the apical ATP-binding cassette (ABC) drug efflux transporters, breast cancer resistance protein (BCRP/ABCG2), P-glycoprotein (ABCB1), and MRP2 (ABCC2) using MDCKII cells transduced with human MDR1, MRP2, and… CONTINUE READING

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