Transport of Pregabalin in Rat Intestine and Caco-2 Monolayers

@article{Jezyk1999TransportOP,
  title={Transport of Pregabalin in Rat Intestine and Caco-2 Monolayers},
  author={Nancy Jezyk and Cheng Li and Barbra H. Stewart and Xiaochun Wu and Howard N. Bockbrader and David F Fleisher},
  journal={Pharmaceutical Research},
  year={1999},
  volume={16},
  pages={519-526}
}
Purpose. The purpose of this study was to determine if the intestinal transport of pregabalin (isobutyl -γ-aminobutyric acid, isobutyl GAB A), a new anticonvulsant drug, was mediated by amino acid carriers with affinity for large neutral amino acids (LNAA). Methods. Pregabalin transport was studied in rat intestine and Caco-2 monolayers. An in vitro Ussing/diffusion chamber model and an in situ single-pass perfusion model were used to study rat intestinal transport. An in vitro diffusion… CONTINUE READING
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