Transport of Phosphatidylserine from the Endoplasmic Reticulum to the Site of Phosphatidylserine Decarboxylase2 in Yeast

@article{Kannan2015TransportOP,
  title={Transport of Phosphatidylserine from the Endoplasmic Reticulum to the Site of Phosphatidylserine Decarboxylase2 in Yeast},
  author={Muthukumar Kannan and Wayne R. Riekhof and Dennis R. Voelker},
  journal={Traffic},
  year={2015},
  volume={16}
}
Over the past two decades, most of the genes specifying lipid synthesis and metabolism in yeast have been identified and characterized. Several of these biosynthetic genes and their encoded enzymes have provided valuable tools for the genetic and biochemical dissection of interorganelle lipid transport processes in yeast. One such pathway involves the synthesis of phosphatidylserine (PtdSer) in the endoplasmic reticulum (ER), and its non‐vesicular transport to the site of phosphatidylserine… Expand
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TLDR
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TLDR
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TLDR
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TLDR
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TLDR
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TLDR
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A protein and lipid interaction network defines key participants in PS transport to the locus of PtdSer-decarboxylase 2, and predicts that this process involves an acceptor membrane complex containing the C2 domains of Psd2p, PstB 2p, and Pbi1p that ligate to Scs2p and phosphatidic acid present in the donor membrane, forming a zone of apposition that facilitates PTDSer transfer. Expand
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TLDR
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