Transport of N-acetyl-D-mannosamine and N-acetyl-D-glucosamine in Escherichia coli K1: effect on capsular polysialic acid production.

@article{RevillaNun2002TransportON,
  title={Transport of N-acetyl-D-mannosamine and N-acetyl-D-glucosamine in Escherichia coli K1: effect on capsular polysialic acid production.},
  author={Beatriz Revilla-Nu{\'i}n and Angel Reglero and Honorina Mart{\'i}nez-Blanco and Ignacio G. Bravo and Miguel Angel Alberto Ferrero and Leandro B. Rodr{\'i}guez-Aparicio},
  journal={FEBS letters},
  year={2002},
  volume={511 1-3},
  pages={
          97-101
        }
}
N-Acetyl-D-mannosamine (ManNAc) and N-acetyl-D-glucosamine (GlcNAc) are the essential precursors of N-acetylneuraminic acid (NeuAc), the specific monomer of polysialic acid (PA), a bacterial pathogenic determinant. Escherichia coli K1 uses both amino sugars as carbon sources and uptake takes place through the mannose phosphotransferase system transporter, a phosphoenolpyruvate-dependent phosphotransferase system that shows a broad range of specificity. Glucose, mannose, fructose, and… CONTINUE READING

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