Transport of Levofloxacin in the OK Kidney Epithelial Cell Line: Interaction with p-Aminohippurate Transport

@article{Matsuo2001TransportOL,
  title={Transport of Levofloxacin in the OK Kidney Epithelial Cell Line: Interaction with p-Aminohippurate Transport},
  author={Yumiko Matsuo and Ikuko Yano and Yasushi Habu and Toshiaki Katsura and Yukiya Hashimoto and Ken–ichi Inui},
  journal={Pharmaceutical Research},
  year={2001},
  volume={18},
  pages={573-578}
}
AbstractPurpose. To evaluate the mechanism of renal transport of quinolone antibacterial drugs, we examined the interaction of levofloxacin with p–aminohippurate (PAH) transport systems and the transport of levofloxacin in renal epithelial cells. Methods. Transport of [14C]PAH or [14C]levofloxacin was measured using OK cell monolayers grown on microporous membrane filters. Results. Transcellular transport from the basolateral to the apical side and cellular accumulation of [14C]PAH were… CONTINUE READING

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