Transport of L-arginine and nitric oxide formation in human platelets.

  title={Transport of L-arginine and nitric oxide formation in human platelets.},
  author={Maria Grazia Signorello and Raffaele Pascale and Giuliana Leoncini},
  journal={European journal of biochemistry},
  volume={270 9},
The results of the present study show that human platelets take up l-arginine by two transport systems which are compatible with the systems y+ and y+L. These Na+independent transporters have been distinguished by treating platelets with N-ethylmaleimide that blocks selectively system y+. System y+, that accounts for 30-40% of the total transport, is characterized by low affinity for l-arginine, is unaffected by l-leucine, is sensitive to changes of membrane potential and to trans-stimulation… CONTINUE READING

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