Transport of Bile Acids, Sulfated Steroids, Estradiol 17-β-d-Glucuronide, and Leukotriene C4 by Human Multidrug Resistance Protein 8 (ABCC11)

@article{Chen2005TransportOB,
  title={Transport of Bile Acids, Sulfated Steroids, Estradiol 17-β-d-Glucuronide, and Leukotriene C4 by Human Multidrug Resistance Protein 8 (ABCC11)},
  author={Z. Chen and Y. Guo and M. Belinsky and E. Kotova and G. Kruh},
  journal={Molecular Pharmacology},
  year={2005},
  volume={67},
  pages={545 - 557}
}
We previously determined that expression of human multidrug resistance protein (MRP) 8, a recently described member of the MRP family of ATP-binding cassette transporters, enhances cellular extrusion of cyclic nucleotides and confers resistance to nucleotide analogs (J Biol Chem 278:29509–29514, 2003). However, the in vitro transport characteristics of the pump have not been determined. In this study, the substrate selectivity and biochemical activity of MRP8 is investigated using membrane… Expand
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