Transport enhancement and reversal: Glucose and 3‐O‐methyl glucose

@article{Musliner1977TransportEA,
  title={Transport enhancement and reversal: Glucose and 3‐O‐methyl glucose},
  author={Thomas A. Musliner and George P. Chrousos and Harold Amos},
  journal={Journal of Cellular Physiology},
  year={1977},
  volume={91}
}
In chick embryo fibroblast cultures the 15‐ to 30‐fold enhancement of D‐glucose uptake observed when cells are starved of glucose for 24 hours is not duplicated for derivatives of glucose that compete effectively for uptake and have generally been considered to use the same carrier. 2‐deoxy‐D‐glucose, D‐mannose, D‐galactose and D‐glucosamine are derepressed progressively less sharply in that order with glucosamine uptake never more than doubled by starvation. D‐glucose at a concentration of 5.5… Expand
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Regulation of sugar transport in cultured diploid human skin fibroblasts
TLDR
The data indicate that hexose transport regulation in cultured human fibrob asts involves protein synthesis of hexose carriers balanced by interactions of glucose with a regulatory protein(s) and glucose metabolism as they affect the regulation and/or turnover of the carrier molecules. Expand
Density‐dependent and adaptive regulation of glucose transport in primary cell cultures of the R3230AC rat mammary adenocarcinoma
  • R. Gay, R. Hilf
  • Biology, Medicine
  • Journal of cellular physiology
  • 1980
TLDR
The experiments suggest that the adaptive regulation of glucose transport in these mammary tumor cell cultures occurred at the transcriptional level and was influenced by the rates of cellular growth. Expand
Hexose transport in normal and SV40‐transformed human endothelial cells in culture
TLDR
The mechanism of glucose entry into human vascular endothelial cells was studied in monolayer cultures of normal and virally transformed umbilical vein endothelium and indicated the presence of a saturable, stereospecific hexose carrier mechanism in both cell types. Expand
Regulation of hexose transport in L8 myocytes by glucose: Possible sites of interaction
TLDR
Results indicate that continuous protein synthesis and protein glycosylation are required for the maintenance of the steady‐state dGlc uptake, and suggest that glucose exerts its autoregulatory effect on hexose transport by modifying the incorporation of active glucose transporters into the plasma membrane rather than changing their rate of degradation. Expand
Control of sugar transport in human fibroblasts independent of glucose metabolism or carrier-substrate interaction.
TLDR
The effect of 3-OMG may be independent of glucose metabolism but it is possible that 3- OMG structurally mimics a metabolite of glucose that may interact with intracellular regulators of carrier degradation and or expression. Expand
Regulation of hexose transport in respiration deficient hamster lung fibroblasts
TLDR
The data indicate that the G14 mutant has been significantly and specifically affected in the expression of sugar transport activity and in the regulatory controls affecting sugar transportActivity. Expand
Rapid Cellular Regulation of D‐Glucose Transport in Cultured Neural Cells
TLDR
The findings suggest the close functional coupling between transport and phosphorylation required for the regulation of glucose transport by cellular metabolic needs. Expand
Regulation of glucose carriers in chick fibroblasts.
TLDR
The synthesis and accumulation of putative mRNA for the carrier protein(s) can be demonstrated by inhibiting protein synthesis with cycloheximide and the regulation of carrier density in the membrane of chick fibroblasts may be achieved entirely by carrier inactivation. Expand
Hexose specificity for downregulation of HepG2/brain-type glucose transporter gene expression in L6 myocytes
TLDR
There are independent pathways for hexose regulation of transport activity, protein and mRNA and down-regulation of transporter mRNA requires metabolism beyond hexose phosphate whereas glucose uptake may be regulated by direct interaction of hexoses with the transporter. Expand
Evidence for the autocrine inhibition of glycolysis in human fibroblasts.
TLDR
Medium conditioned by cells exposed to 3-O-methylglucose did not inhibit glycolysis in glucose-starved cells even though long-term exposure to this hexose, like glucose, results in the repression of transport. Expand
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References

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