Transport characteristics of endomorphin-2 analogues in brain capillary endothelial cells.

Abstract

Because of their poor metabolic stability and limited blood-brain barrier permeability, endomorphins have a low analgesic efficacy when administered systemically. Therefore, it is of great importance to design analogues with improved peptidase resistance and better delivery to the central nervous system. Recently, novel endomorphin-2 analogues have been… (More)
DOI: 10.1111/j.1747-0285.2011.01306.x

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