Transport and signaling through the phosphate-binding site of the yeast Pho84 phosphate transceptor.

@article{Popova2010TransportAS,
  title={Transport and signaling through the phosphate-binding site of the yeast Pho84 phosphate transceptor.},
  author={Yulia Popova and Palvannan Thayumanavan and Elena Lonati and Margarida Agroch{\~a}o and Johan M Thevelein},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2010},
  volume={107 7},
  pages={2890-5}
}
A novel concept in eukaryotic signal transduction is the use of nutrient transporters and closely related proteins as nutrient sensors. The action mechanism of these "transceptors" is unclear. The Pho84 phosphate transceptor in yeast transports phosphate and mediates rapid phosphate activation of the protein kinase A (PKA) pathway during growth induction. We have now identified several phosphate-containing compounds that act as nontransported signaling agonists of Pho84. This indicates that… CONTINUE READING

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