Corpus ID: 5777183

Transport and metabolism of glucosamine by cultured Novikoff rat hepatoma cells and effects on nucleotide pools.

@article{Plagemann1973TransportAM,
  title={Transport and metabolism of glucosamine by cultured Novikoff rat hepatoma cells and effects on nucleotide pools.},
  author={Peter G. W. Plagemann and John Erbe},
  journal={Cancer research},
  year={1973},
  volume={33 3},
  pages={
          482-92
        }
}
Summary As estimated from initial uptake rates, the uptake of glucosamine-1- 14 C by cultured Novikoff rat hepatoma cells in glucose-free basal medium follows normal Michaelis-Menten kinetics, with an apparent K m of about 20 mm. Since glucosamine is not accumulated by the cells against a concentration gradient, the main mode of uptake is by facilitated diffusion, but other evidence indicates that glucosamine also enters the cells by simple diffusion. Glucosamine is probably transported by the… Expand
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INFLUENCE OF GLUCOSAMINE ON GLOMERULAR MESEANGIAL CELL 3 TURNOVER: IMPLICATIONS FOR HYPERGLYCEMIA AND HEXOSAMINE PATHWAY
22 Cells exposed to high glucose may undergo hypertrophy, proliferation, and apoptosis, but 23 the role of hexosamine flux in mediating these effects has not been fully elucidated. Accordingly, 24 weExpand
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