Transport and metabolism of ferulic acid through the colonic epithelium.

  title={Transport and metabolism of ferulic acid through the colonic epithelium.},
  author={Laure Poquet and Michael N Clifford and Gary Williamson},
  journal={Drug metabolism and disposition: the biological fate of chemicals},
  volume={36 1},
Ferulic acid is an important antioxidant found in food, beverages, supplements, and herbal medicines. However, its mechanism of absorption in the colon has never been examined, even though this is its main site of in vivo absorption. Ferulic acid was efficiently transported as the free form through an in vitro model for the colonic epithelium consisting of cocultured Caco-2 and mucus-producing HT29-MTX cells, with only a small amount transported as feruloyl-glucuronide or sulfate, together with… CONTINUE READING
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