Transport and metabolism of L-lactate occur in mitochondria from cerebellar granule cells and are modified in cells undergoing low potassium dependent apoptosis.

@article{Atlante2007TransportAM,
  title={Transport and metabolism of L-lactate occur in mitochondria from cerebellar granule cells and are modified in cells undergoing low potassium dependent apoptosis.},
  author={Anna Atlante and Lidia de Bari and Antonella Bobba and Ersilia Marra and Salvatore Passarella},
  journal={Biochimica et biophysica acta},
  year={2007},
  volume={1767 11},
  pages={1285-99}
}
Having confirmed that externally added L-lactate can enter cerebellar granule cells, we investigated whether and how L-lactate is metabolized by mitochondria from these cells under normal or apoptotic conditions. (1) L-lactate enters mitochondria, perhaps via an L-lactate/H+ symporter, and is oxidized in a manner stimulated by ADP. The existence of an L-lactate dehydrogenase, located in the inner mitochondrial compartment, was shown by immunological analysis. Neither the protein level nor the… CONTINUE READING

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