Transport and local metabolism of budesonide and fluticasone propionate in a human bronchial epithelial cell line (Calu-3).

@article{Borchard2002TransportAL,
  title={Transport and local metabolism of budesonide and fluticasone propionate in a human bronchial epithelial cell line (Calu-3).},
  author={Gerrit Borchard and Mar{\'i}a Luz Cassar{\'a} and Peter E H Roemel{\'e} and Bogdan I. Florea and Hans E. Junginger},
  journal={Journal of pharmaceutical sciences},
  year={2002},
  volume={91 6},
  pages={1561-7}
}
Calu-3 cells grown on microporous filters at an air interface for 16-18 days were incubated with the glucocorticosteroid (GCS) budesonide (BUD). Apparent permeability (P(app)) of BUD across Calu-3 cell monolayers was determined. Amount of BUD transported across Calu-3 cells was clearly concentration dependent, and no polarised transport was detected. When… CONTINUE READING