Transport and intracellular accumulation of vitamin C in endothelial cells: relevance to collagen synthesis.

@article{May2005TransportAI,
  title={Transport and intracellular accumulation of vitamin C in endothelial cells: relevance to collagen synthesis.},
  author={J. M. May and Z. Qu},
  journal={Archives of biochemistry and biophysics},
  year={2005},
  volume={434 1},
  pages={
          178-86
        }
}
  • J. M. May, Z. Qu
  • Published 2005
  • Chemistry, Medicine
  • Archives of biochemistry and biophysics
Endothelial cells preserve vascular integrity in part by synthesizing type IV collagen for the basement membrane of blood vessels. Vitamin C, which at physiologic pH is largely the ascorbate mono-anion, both protects these cells from oxidant stress and is required for collagen synthesis. Therefore, cultured endothelial cells were used to correlate intracellular concentrations of ascorbate with its uptake and ability to stimulate collagen release into the culture medium. The kinetics and… Expand
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