Transport and intracellular accumulation of vitamin C in endothelial cells: relevance to collagen synthesis.

@article{May2005TransportAI,
  title={Transport and intracellular accumulation of vitamin C in endothelial cells: relevance to collagen synthesis.},
  author={J. M. May and Z. Qu},
  journal={Archives of biochemistry and biophysics},
  year={2005},
  volume={434 1},
  pages={
          178-86
        }
}
  • J. M. May, Z. Qu
  • Published 2005
  • Chemistry, Medicine
  • Archives of biochemistry and biophysics
Endothelial cells preserve vascular integrity in part by synthesizing type IV collagen for the basement membrane of blood vessels. Vitamin C, which at physiologic pH is largely the ascorbate mono-anion, both protects these cells from oxidant stress and is required for collagen synthesis. Therefore, cultured endothelial cells were used to correlate intracellular concentrations of ascorbate with its uptake and ability to stimulate collagen release into the culture medium. The kinetics and… Expand
Development of ascorbate transporters in brain cortical capillary endothelial cells in culture
Transfer of ascorbic acid across the vascular endothelium: mechanism and self-regulation.
Ascorbic acid efflux and re-uptake in endothelial cells: maintenance of intracellular ascorbate
  • J. M. May, Z. Qu
  • Chemistry, Medicine
  • Molecular and Cellular Biochemistry
  • 2008
Chelation of intracellular iron enhances endothelial barrier function: a role for vitamin C?
  • J. M. May, Z. Qu
  • Chemistry, Medicine
  • Archives of biochemistry and biophysics
  • 2010
Role of vitamin C in the function of the vascular endothelium.
α-Lipoic acid and ascorbate prevent LDL oxidation and oxidant stress in endothelial cells
Oxidized LDL up-regulates the ascorbic acid transporter SVCT2 in endothelial cells
...
1
2
3
4
5
...

References

SHOWING 1-10 OF 33 REFERENCES
Requirement for GSH in recycling of ascorbic acid in endothelial cells.
Ascorbate Transport and Intracellular Concentration in Cerebral Astrocytes
Vitamin C recycling and function in human monocytic U-937 cells.
Ascorbic acid blunts oxidant stress due to menadione in endothelial cells.
Both intracellular and extracellular vitamin C inhibit atherogenic modification of LDL by human vascular endothelial cells.
  • A. Martin, B. Frei
  • Chemistry, Medicine
  • Arteriosclerosis, thrombosis, and vascular biology
  • 1997
...
1
2
3
4
...