Transport and egress of herpes simplex virus in neurons.

  title={Transport and egress of herpes simplex virus in neurons.},
  author={Russell J Diefenbach and Monica Miranda-Saksena and Mark W Douglas and Anthony L Cunningham},
  journal={Reviews in medical virology},
  volume={18 1},
The mechanisms of axonal transport of the alphaherpesviruses, HSV and pseudorabies virus (PrV), in neuronal axons are of fundamental interest, particularly in comparison with other viruses, and offer potential sites for antiviral intervention or development of gene therapy vectors. These herpesviruses are transported rapidly along microtubules (MTs) in the retrograde direction from the axon terminus to the dorsal root ganglion and then anterogradely in the opposite direction. Retrograde… CONTINUE READING


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