Transplanted neural progenitor cells expressing mutant NT3 promote myelination and partial hindlimb recovery in the chronic phase after spinal cord injury.

@article{Kusano2010TransplantedNP,
  title={Transplanted neural progenitor cells expressing mutant NT3 promote myelination and partial hindlimb recovery in the chronic phase after spinal cord injury.},
  author={Kazuo Kusano and Mitsuhiro Enomoto and Takashi Hirai and Pantelis Tsoulfas and Shinichi Sotome and Kenichi Shinomiya and Atsushi Okawa},
  journal={Biochemical and biophysical research communications},
  year={2010},
  volume={393 4},
  pages={812-7}
}
Neutrotrophin-3 (NT3) plays a protective role in injured central nervous system tissues through interaction with trk receptors. To enhance the regeneration of damaged tissue, a combination therapy with cell transplantation and neurotrophins has been under development. We examined whether the transplantation of neural progenitor cells (NPCs) secreting NT3/D15A, a multi-neurotrophin with the capacity to bind both trkB and trkC, would enhance the repair of damaged tissues and the functional… CONTINUE READING

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The cultured NPCs with lentiviral vector containing either GFP or NT3/D15A were transplanted into the contused spinal cord at 6 weeks after the initial thoracic injury .
The cultured NPCs with lentiviral vector containing either GFP or NT3/D15A were transplanted into the contused spinal cord at 6 weeks after the initial thoracic injury .
Neutrotrophin-3 ( NT3 ) plays a protective role in injured central nervous system tissues through interaction with trk receptors .
Neutrotrophin-3 ( NT3 ) plays a protective role in injured central nervous system tissues through interaction with trk receptors .
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