Transplanted lungs and the “white plague”

  title={Transplanted lungs and the “white plague”},
  author={Nadim Cassir and Robin Delacroix and Carine Gomez and V{\'e}ronique Secq and Martine Reynaud‐Gaubert and Pascal Alexandre Thomas and Laurent Papazian and Michel Drancourt},
Rationale: Solid organ transplant recipients, especially after lung transplantation, are at increased risk for Mycobacterium tuberculosis pulmonary tuberculosis due to lifelong immunosuppression. Patient concerns: A 41-year-old woman underwent a second bilateral lung transplantation that was complicated by fatal pulmonary tuberculosis. Diagnoses: Histological examination of a lung biopsy performed 6 weeks after retransplantation revealed a caseating granuloma and necrosis. Acid-fast bacilli… 
Management and prophylaxis of bacterial and mycobacterial infections among lung transplant recipients.
A comprehensive approach that includes pre-transplant evaluation, perioperative prophylaxis, long-term antimicrobial prophYLaxis, immunization, and safer living at home and in the community, should be employed to minimize the risk of infection.
Anatomic and Cellular Niches for Mycobacterium tuberculosis in Latent Tuberculosis Infection
Latent tuberculosis has been recognized for over a century, but discovery of new niches, where Mycobacterium tuberculosis resides, continues, highlighting that mesenchymal and hematopoietic stem cells harbor organisms in sensitized asymptomatic individuals.


Transmission of Mycobacterium Tuberculosis Via Lung Transplantation
  • K. Winthrop, B. Kubak, J. Flood
  • Medicine
    American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons
  • 2004
A case of pulmonary TB in a double‐lung transplant recipient was investigated, and molecular methods were used to compare the lung recipient's isolate with others from three sources: her hospital, the California state health department's genotyping database, and the donor's resident‐nation of Guatemala.
Challenging issues in tuberculosis in solid organ transplantation.
Through a careful review of posttransplant tuberculosis cases, a history of treated tuberculosis in SOT recipients is identified as a risk factor for development of postTransplant active tuberculosis.
Mycobacterium tuberculosis in lung transplant recipients.
A case of a patient who died of disseminated M. tuberculosis 12 wk after lung transplantation is reported, and tuberculous infections in lung transplant recipients are reviewed.
Pulmonary tuberculosis after lung transplantation.
It is concluded that Mycobacterium tuberculosis may be transmitted directly by a donor lung and may involve bronchial mucosa, pulmonary parenchyma, and pleura.
Mycobacterium tuberculosis infection in solid-organ transplant recipients: impact and implications for management.
  • N. Singh, D. Paterson
  • Medicine, Biology
    Clinical infectious diseases : an official publication of the Infectious Diseases Society of America
  • 1998
Overall, the mortality rate among 499 patients was 29%; disseminated infection, prior rejection, and receipt of OKT3 or anti-T cell antibodies were significant predictors of mortality in patients with tuberculosis.
Mycobacterial infections in solid organ transplant recipients.
This review and consensus manuscript is based on the updated published information and expert recommendations and attempts to provide useful recommendations for each transplant period and problem concerning mycobacterial infections in SOT recipients.
Transmission of Mycobacterium tuberculosis to recipients of single lung transplants from the same donor.
These cases are the first report of two single lung recipients developing pulmonary tuberculosis from a common donor, and restriction fragment length polymorphism analysis on both isolates of M. tuberculosis revealed a common source.
Multidrug resistant tuberculosis following lung transplantation: treatment with pulmonary resection.
This is the first report of multidrug resistant tuberculosis in a lung transplant recipient and the need for a non-conservative approach, including pulmonary resection, to eradicate the infection is emphasised.
Tuberculosis in solid-organ transplant recipients: consensus statement of the group for the study of infection in transplant recipients (GESITRA) of the Spanish Society of Infectious Diseases and Clinical Microbiology.
A series of recommendations regarding the types of drugs and the duration of treatment of tuberculosis in solid-organ recipients are established, giving special attention to pharmacological interactions between rifampin and immunosuppressive drugs.
Multidrug-resistant tuberculosis in a lung transplant recipient.
  • J. Lee, W. Yew, Chi-fong Wong, P. Wong, C. Chiu
  • Medicine, Biology
    The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation
  • 2003