Transplanted iNSCs migrate through SDF-1/CXCR4 signaling to promote neural recovery in a rat model of spinal cord injury.

@article{Ma2014TransplantedIM,
  title={Transplanted iNSCs migrate through SDF-1/CXCR4 signaling to promote neural recovery in a rat model of spinal cord injury.},
  author={Jie Ma and Xin Li and Bo Yi and Hui Yao and Hao Zhao and Yesen Zhang and Xiaochong Zhang and Ning Liu and Zhongqiu Tian and Yiwu Dai},
  journal={Neuroreport},
  year={2014},
  volume={25 6},
  pages={
          391-7
        }
}
The ability of transplanted induced neural stem cells (iNSCs) to promote functional recovery after spinal cord injury and the mechanism by which iNSCs migrate to injured areas are poorly understood. Stromal cell-derived factor-1 (SDF-1) is a cytokine, whereas CXCR4 is its cognate receptor. The aim of this study was to determine whether SDF-1 regulates the migration of iNSCs and to explore the potential mechanism by which iNSCs promotes functional recovery. In-vitro experiments demonstrated that… CONTINUE READING
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