Transplanted Late Outgrowth Endothelial Progenitor Cells as Cell Therapy Product for Stroke

  title={Transplanted Late Outgrowth Endothelial Progenitor Cells as Cell Therapy Product for Stroke},
  author={Chahrazad Moubarik and Benjamin Alain Guillet and Bennis Youssef and Jean-Laurent Codaccioni and Marie-Dominique Piercecchi and Florence Sabatier and Pellegrini Lionel and Laetitia Dou and Alexandrine Foucault-Bertaud and Lionel J Velly and Françoise Dignat-George and Pascale M Pisano},
  journal={Stem Cell Reviews and Reports},
Endothelial progenitor cells (EPCs) seem to be a promising option to treat patients with ischemic diseases. Here, we investigated the effects of late outgrowth EPCs, or endothelial colony-forming cells (ECFCs), a recently defined homogeneous subtype of EPCs, in a rat model of transient middle cerebral artery occlusion (MCAO). Either vehicle or 4.106 ECFCs, isolated from human cord blood, were intravenously injected 24 h after 1 h MCAO in rats assigned to control and transplanted groups… CONTINUE READING


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a potential shift in pathophysiological and therapeutical concepts

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