Transplantation tolerance induced by intranasal administration of HY peptides.

@article{Chai2004TransplantationTI,
  title={Transplantation tolerance induced by intranasal administration of HY peptides.},
  author={Jianshe Chai and Edward James and Hamlata Dewchand and E. Hatheway Simpson and Diane M. Scott},
  journal={Blood},
  year={2004},
  volume={103 10},
  pages={
          3951-9
        }
}
Induction of antigen-specific tolerance to transplantation antigens is desirable to control host-versus-graft and graft-versus-host reactions. Following molecular identification of a set of minor histocompatibility (H) antigens, we have used selected HY peptide epitopes for this purpose. Intranasal administration of individual major histocompatibility complex (MHC) class II-restricted HY peptides induces indefinite survival of syngeneic male skin grafts and allows engraftment of male bone… CONTINUE READING

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