Transplantation tolerance induced by intranasal administration of HY peptides.

@article{Chai2004TransplantationTI,
  title={Transplantation tolerance induced by intranasal administration of HY peptides.},
  author={Jian-Guo Chai and E. James and H. Dewchand and E. Simpson and D. Scott},
  journal={Blood},
  year={2004},
  volume={103 10},
  pages={
          3951-9
        }
}
  • Jian-Guo Chai, E. James, +2 authors D. Scott
  • Published 2004
  • Biology, Medicine
  • Blood
  • Induction of antigen-specific tolerance to transplantation antigens is desirable to control host-versus-graft and graft-versus-host reactions. Following molecular identification of a set of minor histocompatibility (H) antigens, we have used selected HY peptide epitopes for this purpose. Intranasal administration of individual major histocompatibility complex (MHC) class II-restricted HY peptides induces indefinite survival of syngeneic male skin grafts and allows engraftment of male bone… CONTINUE READING
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