Transplantation tolerance in an age of induced pluripotency.


PURPOSE OF REVIEW In a seminal paper in 2006, Yamanaka and coworkers reported the reprogramming of terminally differentiated murine cells to a pluripotent state, largely indistinguishable from conventional embryonic stem cells. The introduction of defined transcription factors via retroviral transduction revealed, in principle, how pluripotency, once… (More)
DOI: 10.1097/MOT.0b013e32832e9424