Transplantation of spermatogonial stem cells isolated from leukemic mice restores fertility without inducing leukemia.

@article{Fujita2005TransplantationOS,
  title={Transplantation of spermatogonial stem cells isolated from leukemic mice restores fertility without inducing leukemia.},
  author={K. Fujita and H. Ohta and A. Tsujimura and T. Takao and Y. Miyagawa and S. Takada and K. Matsumiya and Teruhiko Wakayama and A. Okuyama},
  journal={The Journal of clinical investigation},
  year={2005},
  volume={115 7},
  pages={
          1855-61
        }
}
  • K. Fujita, H. Ohta, +6 authors A. Okuyama
  • Published 2005
  • Medicine
  • The Journal of clinical investigation
  • More than 70% of patients survive childhood leukemia, but chemotherapy and radiation therapy cause irreversible impairment of spermatogenesis. Although autotransplantation of germ cells holds promise for restoring fertility, contamination by leukemic cells may induce relapse. In this study, we isolated germ cells from leukemic mice by FACS sorting. The cell population in the high forward-scatter and low side-scatter regions of dissociated testicular cells from leukemic mice were analyzed by… CONTINUE READING
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