Transplantation of rat metanephroi into mice.

  title={Transplantation of rat metanephroi into mice.},
  author={Sharon A. Rogers and Marc R. Hammerman},
  journal={American journal of physiology. Regulatory, integrative and comparative physiology},
  volume={280 6},
To determine whether transplanted metanephroi grow and differentiate after implantation into the omentum in hosts of a different species, we implanted metanephroi from embryonic day 15 (E15) rat embryos into uninephrectomized mice (hosts). Some host mice received human CTLA4Ig (hCTLA4Ig), anti-CD45RB, and anti-CD154 (tolerance-inducing agents). E15 metanephroi contained only metanephric blastema, segments of ureteric bud, and primitive nephrons with no glomeruli. Rat metanephroi did not grow or… CONTINUE READING


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