Transplantation of purified CD34+ cells in the treatment of critical limb ischemia.

@article{Dong2013TransplantationOP,
  title={Transplantation of purified CD34+ cells in the treatment of critical limb ischemia.},
  author={Zhihui Dong and Bingguang Chen and Wei Guo Fu and Yuqi Wang and Daqiao Guo and Zheng Wei and Xin Xu and Farrell Owen Mendelsohn},
  journal={Journal of vascular surgery},
  year={2013},
  volume={58 2},
  pages={404-411.e3}
}
BACKGROUND This study investigated the feasibility, safety, and efficacy of the intramuscular injection of CD34+ cells isolated from peripheral blood mononuclear cells (PB-MNCs) mobilized by granulocyte colony-stimulating factor (G-CSF) for the management of patients with critical limb ischemia (CLI) who were considered unlikely to have successful long-term revascularization with open bypass or endovascular methods. Cell therapy represents a new treatment modality for this subgroup of patients… CONTINUE READING