Transplantation of preconditioned schwann cells in peripheral nerve grafts after contusion in the adult spinal cord. Improvement of recovery in a rat model.

@article{Rasouli2006TransplantationOP,
  title={Transplantation of preconditioned schwann cells in peripheral nerve grafts after contusion in the adult spinal cord. Improvement of recovery in a rat model.},
  author={Alexandre Rasouli and Nitin Bhatia and Sourabh Suryadevara and Kim Cahill and Ranjan Sen Gupta},
  journal={The Journal of bone and joint surgery. American volume},
  year={2006},
  volume={88 11},
  pages={2400-10}
}
BACKGROUND Recovery after injury to the peripheral nervous system is based on the pro-regenerative relationship between axons and the extracellular matrix, a relationship established by Schwann cells. As mechanical conditioning of Schwann cells has been shown to stimulate their regenerative behavior, we sought to determine whether transplantation of these cells to the central nervous system (i.e., the spinal cord), with its limited regenerative capacity after injury, would improve axonal… CONTINUE READING
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