Transplantation of neural stem cells expressing hypoxia-inducible factor-1alpha (HIF-1alpha) improves behavioral recovery in a rat stroke model.

@article{Wu2010TransplantationON,
  title={Transplantation of neural stem cells expressing hypoxia-inducible factor-1alpha (HIF-1alpha) improves behavioral recovery in a rat stroke model.},
  author={Wanfu Wu and Xiu Chen and Changlin Hu and Jinfang Li and Zhen Yu and Wenqin Cai},
  journal={Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia},
  year={2010},
  volume={17 1},
  pages={92-5}
}
We explored the possibility that hypoxia-inducible factor-1alpha (HIF-1alpha) might contribute to the therapeutic effect of neural stem cell (NSC) transplantation in cerebral ischemia. The relative efficacy of modified NSC to promote behavioral recovery was investigated in a rat model of stroke induced by a transient middle cerebral artery occlusion (MCAO). A recombinant adenovirus (Ad-HIF-1alpha) was engineered to express HIF-1alpha. Control NSC infected with control adenovirus (NSC-Ad… CONTINUE READING