Transplantation of myoblast sheets that secrete the novel peptide SVVYGLR improves cardiac function in failing hearts.

@article{Uchinaka2013TransplantationOM,
  title={Transplantation of myoblast sheets that secrete the novel peptide SVVYGLR improves cardiac function in failing hearts.},
  author={A. Uchinaka and N. Kawaguchi and Y. Hamada and S. Mori and S. Miyagawa and A. Saito and Y. Sawa and N. Matsuura},
  journal={Cardiovascular research},
  year={2013},
  volume={99 1},
  pages={
          102-10
        }
}
AIMS Transplantation of myoblast sheets is a promising therapy for enhancing cardiac function after heart failure. We have previously demonstrated that a 7-amino-acid sequence (Ser-Val-Val-Tyr-Gly-Leu-Arg) derived from osteopontin (SV peptide) induces angiogenesis. In this study, we evaluated the long-term therapeutic effects of myoblast sheets secreting SV in a rat infarction model. METHODS AND RESULTS Two weeks after ligation of the left anterior descending coronary artery, the animals were… Expand
Improvement of cardiac function after implanting the osteopontin-derived peptide SVVYGLR in a hamster model of dilated cardiomyopathy.
Laminin &agr;2-secreting fibroblasts enhance the therapeutic effect of skeletal myoblast sheets
  • A. Uchinaka, Kanako Tasaka, +11 authors N. Kawaguchi
  • Medicine
  • European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery
  • 2017
Cardioprotective effects on ischemic myocardium induced by SVVYGLR peptide via its angiogenic-promoting activity
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Evaluation of dermal wound healing activity of synthetic peptide SVVYGLR.
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Osteopontin-derived peptide SVVYGLR induces angiogenesis in vivo.
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