Transplantation of mesenchymal stem cells cultured on biomatrix support induces repairing of digestive tract defects, in animal model.

@article{SrbuBoei2009TransplantationOM,
  title={Transplantation of mesenchymal stem cells cultured on biomatrix support induces repairing of digestive tract defects, in animal model.},
  author={Mirela-Patricia S{\^i}rbu-Boeţi and Mihaela Chivu and Liliana Livia P{\^a}slaru and Catalin Iulian Efrimescu and Vlad Herlea and Cătălin Pecheanu and Lucia Moldovan and Laura Dragomir and Coralia Bleotu and Elena Ciucur and Cristina Vidulescu and Mihaela Vasilescu and Anişoara Boicea and Sorin Mănoiu and Mihnea Ioan Ionescu and Irinel Popescu},
  journal={Chirurgia},
  year={2009},
  volume={104 1},
  pages={55-65}
}
Transplanted mesenchymal stem cells (MSCs) appear to play a significant role in adult tissue repair. The aim of this research was to obtain MSCs enriched, three dimensional (3D) patches for transplant, and to test their ability to induce repair of iatrogenic digestive tract defects in rats. MSCs were obtained from human and rat bone marrow, cultured in vitro, and seeded in a collagen-agarose scaffold, where they showed enhanced viability and proliferation. The phenotype of the cultured cells… CONTINUE READING