Transplantation of mesenchymal stem cells and nucleus pulposus cells in a degenerative disc model in rabbits: a comparison of 2 cell types as potential candidates for disc regeneration.

@article{Feng2011TransplantationOM,
  title={Transplantation of mesenchymal stem cells and nucleus pulposus cells in a degenerative disc model in rabbits: a comparison of 2 cell types as potential candidates for disc regeneration.},
  author={Ganjun Feng and Xianfeng Zhao and Hao Liu and Huina Zhang and Xiangjun Chen and Rui Shi and Xi Liu and Xiaodan Zhao and Wenli Zhang and Beiyu Wang},
  journal={Journal of neurosurgery. Spine},
  year={2011},
  volume={14 3},
  pages={
          322-9
        }
}
OBJECT The aim of this study was to compare transplanted mesenchymal stem cells (MSCs) with nucleus pulposus cells (NPCs) in a degenerative disc model in rabbits to determine the better candidate for disc cell therapy. METHODS Mesenchymal stem cells and NPCs were transplanted in a rabbit model of disc degeneration. Changes in disc height, according to plain radiography, T2-weighted signal intensity on MR imaging, histology, sulfated glycosaminoglycan (sGAG)/DNA, and associated gene expression… CONTINUE READING

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References

Publications referenced by this paper.
SHOWING 1-10 OF 38 REFERENCES

An in vitro study investigating the survival and phenotype of mesenchymal stem cells following injection into nucleus pulposus tis

CL LeMaitre, P Baird, AJ Freemont, JA Hoyland
  • 2009

An in vitro study investigating the survival and phenotype of mesenchymal stem cells following injection into nucleus pulposus tissue

CL Le Maitre, P Baird, AJ Freemont, JA Hoyland
  • Arthritis Res Ther 11:R20,
  • 2009

Feasibility of a stem cell therapy for intervertebral disc degeneration.

  • The spine journal : official journal of the North American Spine Society
  • 2008

Transplantation of mesenchymal stem cells in a canine disc degeneration model.

  • Journal of orthopaedic research : official publication of the Orthopaedic Research Society
  • 2008