Transplantation of human olfactory ensheathing cells elicits remyelination of demyelinated rat spinal cord.

@article{Kato2000TransplantationOH,
  title={Transplantation of human olfactory ensheathing cells elicits remyelination of demyelinated rat spinal cord.},
  author={Takeshi Kato and Osamu Honmou and Toshimitsu Uede and Kazuo Hashi and Jeffery D Kocsis},
  journal={Glia},
  year={2000},
  volume={30 3},
  pages={209-18}
}
Human olfactory ensheathing cells (OECs) were prepared from adult human olfactory nerves, which were removed during surgery for frontal base tumors, and were transplanted into the demyelinated spinal cord of immunosuppressed adult rats. Extensive remyelination was observed in the lesion site: In situ hybridization using a human DNA probe (COT-1) indicated a similar number of COT-1-positive cells and OEC nuclei within the repaired lesion. The myelination was of a peripheral type with large… CONTINUE READING

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