Transplantation of human embryonic stem cell-derived alveolar epithelial type II cells abrogates acute lung injury in mice.

@article{Wang2010TransplantationOH,
  title={Transplantation of human embryonic stem cell-derived alveolar epithelial type II cells abrogates acute lung injury in mice.},
  author={Dachun Wang and John E. Morales and Daniel G. Calame and Joseph L. Alcorn and Rick A Wetsel},
  journal={Molecular therapy : the journal of the American Society of Gene Therapy},
  year={2010},
  volume={18 3},
  pages={625-34}
}
Respiratory diseases are a major cause of mortality and morbidity worldwide. Current treatments offer no prospect of cure or disease reversal. Transplantation of pulmonary progenitor cells derived from human embryonic stem cells (hESCs) may provide a novel approach to regenerate endogenous lung cells destroyed by injury and disease. Here, we examine the therapeutic potential of alveolar type II epithelial cells derived from hESCs (hES-ATIICs) in a mouse model of acute lung injury. When… CONTINUE READING

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