Transplantation of human amniotic cells exerts neuroprotection in MPTP-induced Parkinson disease mice.

@article{Kong2008TransplantationOH,
  title={Transplantation of human amniotic cells exerts neuroprotection in MPTP-induced Parkinson disease mice.},
  author={Xiang-ying Kong and Zhe Cai and Lin Pan and Lan Zhang and Jun Shu and Yi-long Dong and Nan Yang and Qing Li and Xiao-jie Huang and Ping-Ping Zuo},
  journal={Brain research},
  year={2008},
  volume={1205},
  pages={108-15}
}
To determine the survival and differentiation of cultured Human amniotic cells (HACs) upon transplantation into the brain of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine(MPTP)-induced Parkinson disease (PD) mice. Mouse model of PD was established with injections of MPTP (15 mg/kg, fourth, 2 h interval). After being labeled with PKH26, HACs isolated from human were transplanted into the striatum of PD mice. Immunohistochemistry was performed to evaluate the toxicity of MPTP in the substantia… CONTINUE READING