Transplantation of genetically modified fibroblasts expressing BDNF in adult rats with a subtotal hemisection improves specific motor and sensory functions.

@article{Kim2001TransplantationOG,
  title={Transplantation of genetically modified fibroblasts expressing BDNF in adult rats with a subtotal hemisection improves specific motor and sensory functions.},
  author={Dong Kwan Kim and Timothy J Schallert and Y Liu and T Browarak and Nahid Dehghan Nayeri and Alan R Tessler and Fischer and Marion Murray},
  journal={Neurorehabilitation and neural repair},
  year={2001},
  volume={15 2},
  pages={141-50}
}
OBJECTIVE We have previously reported that grafting fibroblasts genetically modified to express brain-derived neurotrophic factor (BDNF) into a subtotal cervical hemisection site that destroys the entire lateral funiculus will promote regeneration of rubrospinal axons and growth of other axons, prevent atrophy and death of axotomized red nucleus neurons, and improve forelimb use during spontaneous vertical exploration. We have now extended these studies by using additional sensorimotor tests to… CONTINUE READING
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