Transplantation of elastin-secreting myoblast sheets improves cardiac function in infarcted rat heart

@article{Uchinaka2012TransplantationOE,
  title={Transplantation of elastin-secreting myoblast sheets improves cardiac function in infarcted rat heart},
  author={A. Uchinaka and N. Kawaguchi and Y. Hamada and S. Miyagawa and A. Saito and S. Mori and Y. Sawa and N. Matsuura},
  journal={Molecular and Cellular Biochemistry},
  year={2012},
  volume={368},
  pages={203-214}
}
Myoblast sheet transplantation for cardiac failure is a promising therapy to enhance cardiac function via paracrine mechanism. However, their efficacies of treatment showed a gradual decline. The gene modification of the implanted myoblast is important in improving the long-term results of the treatment. Elastin fiber enhances the extensibility of the infarcted wall and can prevent left ventricular dilation. We therefore hypothesized that the elastin gene modification of the implanted myoblast… Expand
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