Transplantation of cultured islets from two-layer preserved pancreases in type 1 diabetes with anti-CD3 antibody.

@article{Hering2004TransplantationOC,
  title={Transplantation of cultured islets from two-layer preserved pancreases in type 1 diabetes with anti-CD3 antibody.},
  author={Bernhard J. Hering and Raja Kandaswamy and James V Harmon and Jeffrey D Ansite and Sue M. Clemmings and Tetsuya Sakai and Stephen Paraskevas and Peter M. Eckman and Junichiro Sageshima and Masahiko Nakano and Toshiya Sawada and Ippei Matsumoto and Hui Jian Zhang and David E. R. Sutherland and Jeffrey A Bluestone},
  journal={American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons},
  year={2004},
  volume={4 3},
  pages={390-401}
}
We sought to determine whether or not optimizing pancreas preservation, islet processing, and induction immunosuppression would facilitate sustained diabetes reversal after single-donor islet transplants. Islets were isolated from two-layer preserved pancreata, purified, cultured for 2 days; and transplanted into six C-peptide-negative, nonuremic, type 1 diabetic patients with hypoglycemia unawareness. Induction immunosuppression, which began 2 days pretransplant, included the Fc receptor… CONTINUE READING

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