Transplantation of cultured human neuronal cells for patients with stroke

  title={Transplantation of cultured human neuronal cells for patients with stroke},
  author={Douglas Kondziolka and Lawrence R. Wechsler and Sidney Goldstein and Carolyn C. Meltzer and Keith R. Thulborn and James M. Gebel and Peter J. Jannetta and Sharon Decesare and Elaine M. Elder and Michael P. Mcgrogan and Miriam A. Reitman and Latonya Bynum},
  pages={565 - 569}
Article abstract Transplantation of cultured neuronal cells is safe in animal models and improves motor and cognitive deficits in rats with stroke. The authors studied the safety and feasibility of human neuronal cellular transplantation in patients with basal ganglia stroke and fixed motor deficits, including 12 patients (aged 44 to 75 years) with an infarct 6 months to 6 years previously (stable for at least 2 months). Serial evaluations (12 to 18 months) showed no adverse cell-related… 

Neurotransplantation for patients with subcortical motor stroke: a phase 2 randomized trial.

This experimental trial indicates the safety and feasibility of neuron transplantation for patients with motor stroke followed by participation in a 2-month stroke rehabilitation program compared with rehabilitation alone in patients with substantial fixed motor deficits associated with a basal ganglia stroke.

Evaluation of Surgical Techniques for Neuronal Cell Transplantation Used in Patients with Stroke

Surgical cell delivery did not lead to new neurological deficits, and imaging studies showed no adverse effects, and the cannula used allowed precise injection of the clinical cell dose within a time period that maintained cell viability.

Stem Cell Treatment for Ischemic Stroke Recovery.

The different biological repair approaches using cell implants are reviewed, clinical trial design and surgical methods are discussed, and the current state of research is discussed.

Clinical Transplantation of Human Embryonic Neural Stem Cells for the Treatment of Cerebral Infarction Sequelae

N SC transplantation can improve cerebral infarction sequelae including motor function and living quality in patients to some extent, however, the long-term effect of NSC transplantation still needs further study.

Stroke repair with cell transplantation: neuronal cells, neuroprogenitor cells, and stem cells.

In animal models of stroke that caused reproducible learning and motor deficits, injection of neuronal cells resulted in a return of learning behavior retention time and motor function.

Neuronal transplantation for motor stroke: from the laboratory to the clinic.

Cell-based treatments for huntington's disease.

Stem cell therapy in stroke

Initial human studies indicate that stem cell therapy may be technically feasible in stroke patients, however, issues still need to be addressed for use in human subjects.

Neural Stem/Progenitor Cell Transplantation for Cortical Visual Impairment in Neonatal Brain Injured Patients

Human NS/PC transplantation is effective to treat patients with severe CVI after neonatal brain injury and showed not only earlier visual improvement but also higher improvement rates and degrees.



Cell transplant therapy for stroke

The only specific therapies we currently have for stroke management are medical methods to prevent inappropriate coagulation, surgical procedures for repair of vascular abnormalities, and

Viability and survival of hNT neurons determine degree of functional recovery in grafted ischemic rats

It is concluded that high cell viability is an important criterion for successful transplantation of cryopreserved neurons derived from cell lines to enhance graft-induced functional effects in rats with cerebral ischemia induced by occlusions.

Transplantation of Cryopreserved Human Embryonal Carcinoma-Derived Neurons (NT2N Cells) Promotes Functional Recovery in Ischemic Rats

The long-term viability of cryopreserved NT2N cell Xenografts in vivo and their sustained effectiveness in promoting behavioral recovery suggest potential utilization of xenografting and Cryopreservation as useful protocols for establishing clone cell lines as graft source in neural transplantation therapies for central nervous system disorders.

Transplanted human neurons derived from a teratocarcinoma cell line (NTera‐2) mature, integrate, and survive for over 1 year in the nude mouse brain

To determine whether NT2N cells can mature into adult neuron‐like cells in vivo, purified NT2n cells were grafted into different regions of the central nervous system of adult and neonatal athymic mice, and the grafts were examined immunohistochemically by light, confocal, and electron microscopy using antibodies to a panel of developmentally regulated neuronal polypeptides.

Restorative neurosurgery: opportunities for restoration of function in acquired, degenerative, and idiopathic neurological diseases.

The landmark advances in the basic and clinical neurosciences and the results of clinical trials that are driving the evolution from passive reaction to disease to active attempts to restore lost central nervous system function are summarized.

Measurements of acute cerebral infarction: a clinical examination scale.

A 15-item neurologic examination stroke scale for use in acute stroke therapy trials was designed and interrater reliability for the scale was found to be high, and test-retest reliability was also high, suggesting acceptable examination and scale validity.

The European Stroke Scale

The European Stroke Scale has been developed according to the clinimetric criteria and internal consistency was excellent, and the R2 values for prognostic validity ranged from 0.45 to 0.81 (P≤.0001).

The MOS 36-ltem Short-Form Health Survey (SF-36): I. Conceptual Framework and Item Selection

A 36-item short-form survey designed for use in clinical practice and research, health policy evaluations, and general population surveys to survey health status in the Medical Outcomes Study is constructed.

Mitral valve replacement.

  • S. Attar
  • Medicine
    Maryland state medical journal
  • 1965

Neurons Derived from a Human Teratocarcinoma Cell Line Establish Molecular and Structural Polarity Following Transplantation into the Rodent Brain

It is concluded that transplanted NT2N cells represent a highly advantageous model system for studies of the developmental biology of neurons and their ability to establish molecular and structural polarity.