Transplantation of bone marrow mononuclear cells prolongs survival, delays disease onset and progression and mitigates neuronal loss in pre-symptomatic, but not symptomatic ALS mice

@article{Venturin2016TransplantationOB,
  title={Transplantation of bone marrow mononuclear cells prolongs survival, delays disease onset and progression and mitigates neuronal loss in pre-symptomatic, but not symptomatic ALS mice},
  author={Gianina Teribele Venturin and Samuel Greggio and Gabriele Zanirati and Daniel Rodrigo Marinowic and Iuri Marques de Oliveira and Jo{\~a}o Antonio P{\^e}gas Henriques and Jaderson Costa Dacosta},
  journal={Neuroscience Letters},
  year={2016},
  volume={633},
  pages={182-188}
}
Cell-based therapy provides a novel strategy to restore lost neurons or modulate the degenerating microenvironment in amyotrophic lateral sclerosis (ALS). This study verified the therapeutic potential of bone marrow mononuclear cells (BMMCs) in SOD1G93A mice. BMMCs were obtained from enhanced green fluorescent protein (EGFP) transgenic C57BL/6 mice (EGFPBMMCs) or from SOD1G93A transgenic mice (mSOD1BMMCs) and given to mice at the pre-symptomatic or late symptomatic stage. Survival, body weight… CONTINUE READING
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