Transplantation of bone marrow genetically engineered to express proinsulin II protects against autoimmune insulitis in NOD mice.


BACKGROUND Type 1 diabetes (T1D) is a T-cell-dependent autoimmune disease resulting from destructive inflammation (insulitis) of the insulin-producing pancreatic beta-cells. Transgenic expression of proinsulin II by a MHC class II promoter or transfer of bone marrow from these transgenic mice protects NOD mice from insulitis and diabetes. We assessed the… (More)


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