Transplantation of bone marrow-derived endothelial progenitor cells attenuates cerebral ischemia and reperfusion injury by inhibiting neuronal apoptosis, oxidative stress and nuclear factor-κB expression.

@article{Qiu2013TransplantationOB,
  title={Transplantation of bone marrow-derived endothelial progenitor cells attenuates cerebral ischemia and reperfusion injury by inhibiting neuronal apoptosis, oxidative stress and nuclear factor-κB expression.},
  author={Jing Qiu and Wei Li and Shuhang Feng and Min Wang and Zhiyi He},
  journal={International journal of molecular medicine},
  year={2013},
  volume={31 1},
  pages={91-8}
}
The aim of the present study was to investigate the neuroprotective effects of bone marrow-derived endothelial progenitor cell (EPC) transplantation against cerebral ischemia/reperfusion (I/R) injury in rats and to delineate the possible underlying mechanisms. Cerebral I/R injury was established by 2 h of middle cerebral artery occlusion (MCAO) followed by reperfusion for 24 h. EPCs were isolated from bone marrow of the donor rats… CONTINUE READING
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Apoptotic mechanisms after cerebral ischemia

  • YS Song, P Narasimhan, GS Kim, JE Jung, EH Park, PH Chan
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