Transplantation of bone marrow cells from transgenic mice expressing the human MDR1 gene results in long-term protection against the myelosuppressive effect of chemotherapy in mice.

@article{Mickisch1992TransplantationOB,
  title={Transplantation of bone marrow cells from transgenic mice expressing the human MDR1 gene results in long-term protection against the myelosuppressive effect of chemotherapy in mice.},
  author={Gerald H. J. Mickisch and Ivona Aksentijevich and Patricia Veronica Schoenlein and Lori J. Goldstein and Hanan Galski and C Stahle and David H Sachs and Ira Pastan and Michael M. Gottesman},
  journal={Blood},
  year={1992},
  volume={79 4},
  pages={1087-93}
}
Many human cancers that are initially responsive to chemotherapy eventually fail to respond to treatment. For some drugs, dose escalation that may be required for a cure cannot be achieved because sensitive tissues such as bone marrow (BM) limit cytotoxic therapy. Approaches to prevent or circumvent BM toxicity are therefore a high priority of research on dose escalation protocols. In this study, we have transplanted BM cells from transgenic mice that constitutively express physiologic amounts… CONTINUE READING

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