Transplantation of allogeneic islets of Langerhans in the rat liver: effects of macrophage depletion on graft survival and microenvironment activation.

@article{Bottino1998TransplantationOA,
  title={Transplantation of allogeneic islets of Langerhans in the rat liver: effects of macrophage depletion on graft survival and microenvironment activation.},
  author={Rita Bottino and Luis A. Fernandez and Camillo Ricordi and Rainer Lehmann and Min-fu Tsan and Robert C. Oliver and Luca Alessandro Inverardi},
  journal={Diabetes},
  year={1998},
  volume={47 3},
  pages={316-23}
}
Early impairment of islet function and graft loss limit the success of allogeneic islet transplantation. Nonspecific inflammatory events occurring at the transplant site immediately after grafting, involving the production of cytokines and free radicals and sinusoidal endothelial cell (SEC) activation, may contribute to islet cell damage. To evaluate whether Kupffer cell inactivation would result in prolonged allograft survival in a model system of intrahepatic islet transplantation in rats, we… CONTINUE READING
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